Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

‘He is the Vagabond that Hath No Habitation in the Lord’: The Representation of Quakerism as Vagrancy in Interregnum England,c. 1650–1660     

David Hitchcock 《Cultural and Social History》2018,15(1):21-37

This article examines the printed representation, and prosecutorial characterisation, of the movements, actions and motivations of early Quakers as vagrant. It argues that the prevalence and power of representing (and subsequently treating) early Quakers as vagrants is an understudied aspect of the social and cultural history of the Society of Friends, particularly in Interregnum England. As evidence, it interrogates a furious pamphlet debate between mid-century religious writers and preachers, who devoted much time and ink to painting Quakers as mendacious vagabonds, and Quaker ‘First Publishers’, who responded at length and in a striking way to these accusations. The article concludes that these images of Quakerism as a form of ‘spiritual vagrancy’ created historically significant echoes in English and Atlantic culture.  相似文献   

国际科研众筹项目的特征描述、主题分析及属性对比:基于Experiment平台的发现     

刘周颖  赵宇翔  巴志超  吴聪  朱庆华 《图书情报知识》2020,(3):71-82

[目的/意义]为了深入了解科研众筹平台中的项目情况,本文对科研众筹项目的基本特征、研究主题和不同类型科研众筹项目的属性对比进行研究。[研究设计/方法]首先对科研众筹的起源、价值和运作模式进行了梳理;随后爬取了科研众筹平台Experiment的项目信息,并对该平台中科研项目的发起者、背书者、项目记录、所属学科、资助情况等进行特征描述;基于LDA模型对科研众筹项目主题进一步细化,并对不同资金筹集和不同主题分类情况下的科研众筹项目的属性差异进行比较分析。[结论/发现]科研众筹主题主要集中在生物学和生态学两个领域,不同资金筹集达成情况的科研众筹项目在项目背书者数量、信息记录次数和讨论次数上具有显著差异;不同主题的科研众筹项目在其讨论次数上具有显著差异。同时,是否提供视频和是否参与资助挑战在不同资金筹集达成情况和不同主题的科研众筹项目上均具有显著差异。[创新/价值]深入分析了科研众筹平台中项目主题及属性对比情况,对科研众筹平台优化信息审核机制、社交机制和信息展示机制具有一定的参考价值。  相似文献   

Ancient Mural Classification Method Based on Improved AlexNet Network     

Jianfang Cao  Hongyan Cui  Qi Zhang  Zibang Zhang 《文物保护研究》2020,65(7):411-423

ABSTRACT

As an important part of art and culture, ancient murals depict a variety of different artistic images, and these individual images have important research value. For research purposes, it is often important to first determine the type of objects represented in a painting. However, the mural painting environment makes datasets difficult to collect, and long-term exposure leads to underlying features that are not distinct, which makes this task challenging. This study proposes a convolutional neural network model based on the classic AlexNet network model and combines it with feature fusion to automatically classify ancient mural images. Due to the lack of large-scale mural datasets, the model first expands the dataset by applying image enhancement algorithms such as scaling, brightness conversion, noise addition, and flipping; then, it extracts the underlying features (such as fresco edges) shared by the first stage of a dual channel structure. Subsequently, a second-stage deep abstraction is conducted on the features extracted by the first stage using a two-channel network, each of which has a different structure. The obtained characteristics from both channels are merged, and a loss function is constructed to obtain the classification result. This approach improves the model's robustness and feature expression ability. The model achieves an accuracy of 84.24%, a recall rate of 84.15%, and an F1-measure of 84.13% when applied to a constructed mural image dataset. Compared with the AlexNet model and other improved convolutional neural network models, the proposed model improves each evaluation index by approximately 5%, verifying the rationality and effectiveness of the model for automatic mural image classification. The mural classification model proposed in this paper comprehensively considers the influences of network width and depth and can extract rich details from mural images from multiple local channels. An effective classification method could help researchers manage and protect mural images in an orderly fashion and quickly and effectively search for target images in a digital mural library based on a specified image category, aiding mural condition monitoring and restoration efforts as well as archaeological and art historical research.  相似文献   

学习团队协作信息搜索的共享心智模型研究   总被引：1，自引：0，他引：1  

颜端武  张馨月  汤佳丽  苏琼 《图书情报工作》2020,64(8):3-12

[目的/意义] 对协作信息搜索进行深入研究，为专业化协作信息搜索系统平台建设优化等提供启发和借鉴。[方法/过程] 聚焦于学习团队的信息搜索行为，以高校学生为研究样本，以共享心智模型为切入点，采用扎根理论研究方法，探讨协作信息搜索中团队共享心智模型建构过程。[结果/结论] 识别出四大核心环节——个体感知与探索、团队任务解析、团队信息收集和团队信息整合，并理清各环节的认知活动与共享心智模型内容要素。  相似文献   

数据管理能力成熟度模型比较研究与启示     

叶兰 《图书情报工作》2020,64(13):51-57

[目的/意义] 对比分析数据管理能力成熟度模型，为图书馆选择与应用数据管理能力成熟度模型提供参考方案。[方法/过程] 通过模型文本的研究，介绍各模型的结构。采用比较分析法从评价维度（功能域）的设置、模型的组织体系、评价标准与规则、可操作性、公开度等5个方面对7个数据管理能力成熟度模型进行评析。[结果/结论] 每个模型具有其特色功能。CMMI、DMM、DCAM和中国DCMM的评价维度较为全面，中国DCMM即中国-数据中心服务能力成熟度模型具有较强的操作性，且其定量与定性相结合的评价方法值得借鉴。研究数据管理的能力成熟度模型（雪城大学秦健教授团队）和研究数据管理能力成熟度模型（澳大利亚ANDS）考虑图书馆数据管理的实际情况，可作为首选模型。基于各模型的对比与评析结果，形成3种适应不同情境的图书馆选择与应用数据管理能力成熟度模型的方案。  相似文献   

基于二模复杂网络的隐性知识发现方法研究——以潜在药物靶点挖掘为例     

李东巧  陈芳  韩涛  杨艳萍  王学昭  王燕鹏  Cynthia Liu  Yingzhu Li 《图书情报工作》2020,64(21):120-129

[目的/意义] 通过构建二模复杂网络模型，揭示隐藏在海量文献中的隐性知识。[方法/过程] 通过NetworkX复杂网络工具包，依据任意两个节点的共现关系构建二模复杂网络模型；对网络模型中节点的共现关系进行加权，计算网络的拓扑信息并进行AP聚类，提取节点间的直接关系；采用AUC方法对AA、JC、加权改进的wAA和wJC等4种链路预测算法进行评价，遴选出最合适的预测算法，并对复杂网络的隐性关系进行预测分析。[结果/结论] 以潜在药物靶点挖掘为例进行的实证研究结果表明，wAA链路预测算法为最优的链路预测算法；二模复杂网络模型、指标和方法体系在美国化学文摘社数据库中的药物靶点挖掘中具有一定的有效性。下一步计划在其他数据库中或其他研究领域中进行尝试，以进一步验证该模型的通用性和有效性。  相似文献   

政府数据开放中的公众参与模式:理论构建与案例实证     

陈朝兵  简婷婷 《图书情报工作》2020,64(22):58-68

[目的/意义] 探讨政府数据开放中公众参与的理论模式，旨在指导政府部门有效实现公众参与数据开放的政策目标，以及推进政府数据开放中公众参与议题的研究进展。[方法/过程] 采用文献分析法、逻辑分析法和案例分析法，同时以公众参与阶梯理论作为分析工具，构建并实证政府数据开放中的公众参与模式。[结果/结论] 政府数据开放中的公众参与可从理论层面构建为告知型参与、咨询型参与、合作型参与和授权型参与4种模式，其核心涵义分别是政府向公众传达信息、政府咨询公众意见、政府与公众平等合作、政府与公众共同治理。这4种政府数据开放公众参与理论模式一方面在政府意图、主导力量、信息流动、公众信息知晓度和公众自治程度方面存在明显的特征差异，另一方面从国内外政府数据开放公众参与实践案例中获得良好的经验支持。  相似文献   

灰色预测法在情报研究中的应用研究综述     

张晶晶  李泽霞 《图书情报工作》2020,64(24):106-114

[目的/意义] 灰色预测法可有效处理情报研究中广泛存在的小样本数据，通过对灰色预测法在情报研究中的应用情况进行梳理，总结其在应用过程中存在的不足，为灰色预测法在情报研究中的进一步应用提供参考。[方法/过程] 通过综述情报研究中涉及灰色预测法的相关文献，从数据选取、模型构建和解决的问题等方面对情报研究中灰色预测法的应用进行概述，总结当前情报研究中灰色预测法的应用所存在的问题，并提出改进建议。[结果/结论] 在方法应用上，已有研究主要采用数列灰预测，且模型集中在单变量灰色预测模型，根据预测对象不同，灰色预测法已经在包括期刊分析、图书馆运行管理、热点主题分析及科研机构评价方面得到了很好的应用，未来可根据预测对象特点及研究目标尝试不同的灰色预测方法，扩宽灰色预测法在其他方面的情报研究问题中的应用。  相似文献   

欧洲九国共产党情报局机关刊物《争取持久和平,争取人民民主!》与中国关系考述(1949-1956)     

哈战荣 《图书馆杂志》2020,(4):21-26

《争取持久和平,争取人民民主!》是20世纪40年代中后期,欧洲九个社会主义国家的共产党和工人党为了一致行动而建立的情报局机关刊物。该刊物对新中国初期我国经济社会建设及成就进行了大量宣传与报道,对加强我国与世界其他爱好和平、渴求民主的各国人民加强互信、长存友谊贡献很大,也对当前学者研究新中国初期我国经济社会发展的过程、成就和经验等提供了原始史料,学术研究意义也很重大。但是,目前对这份刊物及其发挥过的重大作用了解的人少之又少,时值中国共产党成立100周年之际,对其创刊与发行的历史过程进行回顾、宣传中国社会经济发展的全貌进行展示、推动世界社会主义运动的作用进行肯定,意义都很重大。  相似文献